Dusp3 | dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
Physiological systems
20 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton
12 No significant impact
4 Not tested
Data collections
Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased mean corpuscular hemoglobin | 1 supporting dataset | Dusp3tm1a(KOMP)Wtsi | homozygote | Early adult | 5.46x10-7 | ||
| increased total body fat amount | 1 supporting dataset | Dusp3tm1a(KOMP)Wtsi | homozygote | Early adult | 7.24x10-5 | ||
| abnormal humerus morphology | 1 supporting dataset | Dusp3tm1a(KOMP)Wtsi | homozygote | Early adult | 5.39x10-10 | ||
| decreased lean body mass | 1 supporting dataset | Dusp3tm1a(KOMP)Wtsi | homozygote | Early adult | 2.02x10-5 | ||
| decreased bone mineral content | 1 supporting dataset | Dusp3tm1b(KOMP)Wtsi | homozygote | Early adult | 9.91x10-5 | ||
| increased circulating glycerol level | 1 supporting dataset | Dusp3tm1b(KOMP)Wtsi | homozygote | Early adult | 3.32x10-8 | ||
| decreased grip strength | 2 supporting datasets | Dusp3tm1b(KOMP)Wtsi | homozygote | Early adult | 1.41x10-5 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Dusp3tm1a(KOMP)Wtsi | homozygote | Early adult | 2.2x10-5 | ||
| increased circulating insulin level | 1 supporting dataset | Dusp3tm1b(KOMP)Wtsi | homozygote | Early adult | 7.11x10-7 | ||
| decreased circulating creatinine level | 1 supporting dataset | Dusp3tm1a(KOMP)Wtsi | homozygote | Early adult | 4.68x10-5 |
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| adrenal gland | heterozygote | n/a | 40% (4/10) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (1/1) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 100% (10/10) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/8) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (10/10) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/9) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 11.11% (1/9) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Dusp3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dusp3.
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| Dusp3tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dusp3tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Dusp3tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Dusp3tm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |