Dusp3 | dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

GeneMGI:1919599Synonyms: VHR, 2210015O03Rik, +2 more

Physiological systems

20 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton

12 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



increased mean corpuscular hemoglobin	1 supporting dataset	Dusp3^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.46x10^-7
increased total body fat amount	1 supporting dataset	Dusp3^{tm1a(KOMP)Wtsi}	homozygote	Early adult	7.24x10^-5
abnormal humerus morphology	1 supporting dataset	Dusp3^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.39x10^-10
decreased lean body mass	1 supporting dataset	Dusp3^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.02x10^-5
decreased bone mineral content	1 supporting dataset	Dusp3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	9.91x10^-5
increased circulating glycerol level	1 supporting dataset	Dusp3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.32x10^-8
decreased grip strength	2 supporting datasets	Dusp3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.41x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Dusp3^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.2x10^-5
increased circulating insulin level	1 supporting dataset	Dusp3^{tm1b(KOMP)Wtsi}	homozygote	Early adult	7.11x10^-7
decreased circulating creatinine level	1 supporting dataset	Dusp3^{tm1a(KOMP)Wtsi}	homozygote	Early adult	4.68x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dusp3.

Associated images

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Histopathology

There is no histopathology data found for Dusp3.

IMPC related publications

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External links

No external links available for Dusp3.

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*Dusp3^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Dusp3^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Dusp3^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Dusp3^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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