Supt7l | SPT7-like, STAGA complex gamma subunit
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Integument Growth/size/body region Vision/eye
16 No significant impact
5 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| abnormal hair texture | 1 supporting dataset | Supt7ltm1a(EUCOMM)Wtsi | heterozygote | Early adult | 3.72x10-7 | ||
| decreased body weight | 3 supporting datasets | Supt7ltm1a(EUCOMM)Wtsi | heterozygote | Early adult | 1.71x10-6 | ||
| cataract | 1 supporting dataset | Supt7ltm1a(EUCOMM)Wtsi | heterozygote | Early adult | 3.17x10-5 | ||
| abnormal lens morphology | 1 supporting dataset | Supt7ltm1a(EUCOMM)Wtsi | heterozygote | Early adult | 3.31x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 100% (2/2) | 0% (0/173) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Supt7l mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Supt7l.
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| Supt7ltm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Supt7ltm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |