Dscc1 | DNA replication and sister chromatid cohesion 1
Physiological systems
20 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Behavior/neurological Skeleton Mortality/aging
14 No significant impact
4 Not tested
Data collections
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| increased blood urea nitrogen level | 1 supporting dataset | Dscc1tm1a(KOMP)Wtsi | homozygote | Early adult | 1.7x10-9 | ||
| increased lumbar vertebrae number | 1 supporting dataset | Dscc1tm1a(KOMP)Wtsi | homozygote | Early adult | 1.89x10-6 | ||
| decreased circulating HDL cholesterol level | 1 supporting dataset | Dscc1tm1a(KOMP)Wtsi | heterozygote | Early adult | 6.51x10-5 | ||
| abnormal behavior | 1 supporting dataset | Dscc1tm1a(KOMP)Wtsi | heterozygote | Early adult | 2.14x10-5 | ||
| decreased circulating LDL cholesterol level | 1 supporting dataset | Dscc1tm1a(KOMP)Wtsi | heterozygote | Early adult | 4.44x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Dscc1tm1a(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| vertebral fusion | 1 supporting dataset | Dscc1tm1a(KOMP)Wtsi | homozygote | Early adult | 3.12x10-5 | ||
| abnormal rib morphology | 1 supporting dataset | Dscc1tm1a(KOMP)Wtsi | homozygote | Early adult | 9.18x10-5 | ||
| increased bone mineral content | 1 supporting dataset | Dscc1tm1a(KOMP)Wtsi | heterozygote | Early adult | 8.6x10-5 | ||
| decreased total body fat amount | 1 supporting dataset | Dscc1tm1a(KOMP)Wtsi | heterozygote | Early adult | 5.56x10-5 |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Dscc1.
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| Dscc1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dscc1tm42166(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |
| Dscc1tm42166(L1L2_Pgk_PM) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |