Dscc1 | DNA replication and sister chromatid cohesion 1

GeneMGI:1919357Synonyms: 2600005O03Rik, 2010006I05Rik

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Behavior/neurological Skeleton Mortality/aging

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased blood urea nitrogen level	1 supporting dataset	Dscc1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.7x10^-9
increased lumbar vertebrae number	1 supporting dataset	Dscc1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.89x10^-6
decreased circulating HDL cholesterol level	1 supporting dataset	Dscc1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	6.51x10^-5
abnormal behavior	1 supporting dataset	Dscc1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	2.14x10^-5
decreased circulating LDL cholesterol level	1 supporting dataset	Dscc1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	4.44x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Dscc1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
vertebral fusion	1 supporting dataset	Dscc1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	3.12x10^-5
abnormal rib morphology	1 supporting dataset	Dscc1^{tm1a(KOMP)Wtsi}	homozygote	Early adult	9.18x10^-5
increased bone mineral content	1 supporting dataset	Dscc1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	8.6x10^-5
decreased total body fat amount	1 supporting dataset	Dscc1^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	5.56x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dscc1.

Associated images

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Histopathology

There is no histopathology data found for Dscc1.

IMPC related publications

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External links

No external links available for Dscc1.

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*Dscc1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Dscc1^{tm42166(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Dscc1^{tm42166(L1L2_Pgk_PM)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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