Jmjd8 | jumonji domain containing 8
Physiological systems
18 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Homeostasis/metabolism
17 No significant impact
6 Not tested
Data collections
Gene metrics:1Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| decreased circulating iron level | 1 supporting dataset | Jmjd8tm1.1(KOMP)Vlcg | homozygote | Early adult | 2.47x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/2) | 0.41% (2/491) |
| epididymis | heterozygote | n/a | 0% (0/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Jmjd8 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Jmjd8.
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| Jmjd8tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Jmjd8tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Jmjd8tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Jmjd8tm213507(L1L2_Bact_P) | Reporter-tagged deletion allele (with selection cassette) | | targeting vector |
| Jmjd8tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Jmjd8tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Jmjd8tm447383(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |