Ush1c | USH1 protein network component harmonin

GeneMGI:1919338Synonyms: harmonin, 2010016F01Rik, +1 more

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton

11 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



improved glucose tolerance	1 supporting dataset	Ush1c^{tm1a(KOMP)Wtsi}	homozygote	Early adult	4.37x10^-13
trunk curl	1 supporting dataset	Ush1c^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.59x10^-19
absent pinna reflex	1 supporting dataset	Ush1c^{tm1a(KOMP)Wtsi}	homozygote	Early adult	4.66x10^-21
decreased grip strength	4 supporting datasets	Ush1c^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.14x10^-12
stereotypic behavior	1 supporting dataset	Ush1c^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.82x10^-23
increased lean body mass	1 supporting dataset	Ush1c^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.37x10^-8
increased circulating chloride level	1 supporting dataset	Ush1c^{tm1a(KOMP)Wtsi}	homozygote	Early adult	4.17x10^-7
decreased circulating glucose level	1 supporting dataset	Ush1c^{tm1a(KOMP)Wtsi}	homozygote	Early adult	7.85x10^-5
increased circulating sodium level	1 supporting dataset	Ush1c^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.44x10^-5
limb grasping	1 supporting dataset	Ush1c^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.72x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ush1c.

Associated images

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Histopathology

There is no histopathology data found for Ush1c.

IMPC related publications

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External links

No external links available for Ush1c.

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*Ush1c^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ush1c^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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