Slc39a4 | solute carrier family 39 (zinc transporter), member 4

GeneMGI:1919277Synonyms: zip4, AWMS2, +1 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Nervous system Mortality/aging

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

30Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal midbrain development	1 supporting dataset	Slc39a4^{tm1.1(KOMP)Wtsi}	heterozygote	E9.5	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Slc39a4^{tm1.1(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal forebrain development	1 supporting dataset	Slc39a4^{tm1.1(KOMP)Wtsi}	heterozygote	E9.5	N/A ^*
abnormal neural tube closure	1 supporting dataset	Slc39a4^{tm1.1(KOMP)Wtsi}	heterozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Slc39a4^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased fasting circulating glucose level	1 supporting dataset	Slc39a4^{tm1.1(KOMP)Wtsi}	heterozygote	Early adult	9.89x10^-5
abnormal hindbrain development	1 supporting dataset	Slc39a4^{tm1.1(KOMP)Wtsi}	heterozygote	E9.5	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Slc39a4^{tm1.1(KOMP)Wtsi}	homozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Slc39a4.

Associated images

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Histopathology

There is no histopathology data found for Slc39a4.

IMPC related publications

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External links

No external links available for Slc39a4.

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*Slc39a4^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell mouse
*Slc39a4^{tm1.1(KOMP)Wtsi}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Slc39a4^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Slc39a4^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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