Ppp2r2a | protein phosphatase 2, regulatory subunit B, alpha

GeneMGI:1919228Synonyms: 2410004D02Rik

Physiological systems

16 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Growth/size/body region Skeleton Mortality/aging

13 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased bone mineral density	1 supporting dataset	Ppp2r2a^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	9.55x10^-7
preweaning lethality, complete penetrance	1 supporting dataset	Ppp2r2a^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal bone structure	1 supporting dataset	Ppp2r2a^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	4.94x10^-8
decreased lean body mass	2 supporting datasets	Ppp2r2a^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	1.33x10^-10
decreased bone mineral content	2 supporting datasets	Ppp2r2a^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	9.94x10^-8
decreased body length	1 supporting dataset	Ppp2r2a^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	5.51x10^-9

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ppp2r2a.

Associated images

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Histopathology

There is no histopathology data found for Ppp2r2a.

IMPC related publications

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External links

No external links available for Ppp2r2a.

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*Ppp2r2a^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ppp2r2a^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ppp2r2a^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Ppp2r2a^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ppp2r2a^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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