Tmem106b | transmembrane protein 106B

GeneMGI:1919150Synonyms: 6430519M21Rik, 5830455K21Rik, +1 more

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Growth/size/body region Vision/eye Skeleton

16 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

4Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



increased circulating alkaline phosphatase level	1 supporting dataset	Tmem106b^{tm2b(KOMP)Wtsi}	homozygote	Early adult	9.24x10^-62
enlarged epididymis	1 supporting dataset	Tmem106b^{tm2b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased body length	2 supporting datasets	Tmem106b^{tm2b(KOMP)Wtsi}	homozygote	Early adult	1.91x10^-6
increased bone mineral content	1 supporting dataset	Tmem106b^{tm2b(KOMP)Wtsi}	homozygote	Early adult	6.42x10^-5
abnormal retina inner nuclear layer morphology	1 supporting dataset	Tmem106b^em1(IMPC)Bay	homozygote	Early adult	2.85x10^-7
decreased total retina thickness	1 supporting dataset	Tmem106b^em1(IMPC)Bay	homozygote	Early adult	5.69x10^-6
abnormal epididymis morphology	1 supporting dataset	Tmem106b^{tm2b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tmem106b.

Associated images

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Histopathology

There is no histopathology data found for Tmem106b.

IMPC related publications

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External links

No external links available for Tmem106b.

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*Tmem106b^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Tmem106b^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Tmem106b^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Tmem106b^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Tmem106b^{tm2b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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