Acsl5 | acyl-CoA synthetase long-chain family member 5
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Liver/biliary system Hematopoietic system Cardiovascular system
14 No significant impact
3 Not tested
Data collections
Gene metrics:12Significant phenotypes
1Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| decreased circulating glucose level | 1 supporting dataset | Acsl5tm1.1(KOMP)Vlcg | homozygote | Early adult | 4.16x10-6 | ||
| decreased circulating cholesterol level | 1 supporting dataset | Acsl5tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.02x10-11 | ||
| decreased circulating total protein level | 1 supporting dataset | Acsl5tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.39x10-5 | ||
| decreased liver weight | 1 supporting dataset | Acsl5tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.73x10-9 | ||
| increased circulating bilirubin level | 1 supporting dataset | Acsl5tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.21x10-7 | ||
| decreased circulating triglyceride level | 1 supporting dataset | Acsl5tm1.1(KOMP)Vlcg | homozygote | Early adult | 3.19x10-6 | ||
| increased heart weight | 2 supporting datasets | Acsl5tm1.1(KOMP)Vlcg | homozygote | Early adult | 3.22x10-5 | ||
| cornea opacity | 1 supporting dataset | Acsl5tm1.1(KOMP)Vlcg | homozygote | Early adult | 1.87x10-9 | ||
| increased spleen weight | 1 supporting dataset | Acsl5tm1.1(KOMP)Vlcg | homozygote | Early adult | 5.8x10-5 | ||
| decreased circulating HDL cholesterol level | 1 supporting dataset | Acsl5tm1.1(KOMP)Vlcg | homozygote | Early adult | 4.72x10-10 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images Wholemount images | 100% (3/3) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (3/3) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | Section images | 100% (2/2) | 0% (0/22) |
| brain | heterozygote | Wholemount images | 100% (3/3) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 33.33% (1/3) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | n/a | 50% (1/2) | 7.75% (22/284) |
| cerebellum | heterozygote | Section images Wholemount images | 66.67% (2/3) | 0.56% (3/532) |
Human diseases caused by Acsl5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Acsl5.
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| Acsl5tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Acsl5tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Acsl5tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Acsl5tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |