Fbxo30 | F-box protein 30
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging
13 No significant impact
5 Not tested
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| decreased circulating glucose level | 1 supporting dataset | Fbxo30tm1b(KOMP)Wtsi | heterozygote | Early adult | 1x10-5 | ||
| increased prepulse inhibition | 2 supporting datasets | Fbxo30tm1b(KOMP)Wtsi | heterozygote | Early adult | 1.66x10-5 | ||
| improved glucose tolerance | 1 supporting dataset | Fbxo30tm1b(KOMP)Wtsi | heterozygote | Early adult | 3.87x10-5 | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Fbxo30tm1b(KOMP)Wtsi | heterozygote | Early adult | 5.99x10-5 | ||
| decreased startle reflex | 1 supporting dataset | Fbxo30tm1b(KOMP)Wtsi | heterozygote | Early adult | 2.06x10-5 | ||
| increased bone mineral content | 1 supporting dataset | Fbxo30tm1b(KOMP)Wtsi | heterozygote | Early adult | 5.36x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Fbxo30tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
| hyperactivity | 1 supporting dataset | Fbxo30tm1b(KOMP)Wtsi | heterozygote | Early adult | 8.58x10-5 | ||
| increased bone mineral density | 1 supporting dataset | Fbxo30tm1b(KOMP)Wtsi | heterozygote | Early adult | 5.64x10-5 |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
External links
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| Fbxo30tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Fbxo30tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Fbxo30tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |