Dcaf7 | DDB1 and CUL4 associated factor 7
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Mortality/aging
15 No significant impact
6 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal retina inner nuclear layer morphology | 2 supporting datasets | Dcaf7tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.06x10-5 | ||
| decreased total retina thickness | 1 supporting dataset | Dcaf7tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6.96x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Dcaf7tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating total protein level | 1 supporting dataset | Dcaf7tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.14x10-6 |
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Human diseases caused by Dcaf7 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dcaf7.
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| Dcaf7tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Dcaf7tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dcaf7tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Dcaf7tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |