Dcaf7 | DDB1 and CUL4 associated factor 7

GeneMGI:1919083Synonyms: Wdr68, 2610037L01Rik, +1 more

Physiological systems

18 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Mortality/aging

15 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal retina inner nuclear layer morphology	2 supporting datasets	Dcaf7^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.06x10^-5
decreased total retina thickness	1 supporting dataset	Dcaf7^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.96x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Dcaf7^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating total protein level	1 supporting dataset	Dcaf7^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.14x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dcaf7.

Associated images

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Histopathology

There is no histopathology data found for Dcaf7.

IMPC related publications

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External links

No external links available for Dcaf7.

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*Dcaf7^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Dcaf7^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Dcaf7^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Dcaf7^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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