Plekhf2 | pleckstrin homology domain containing, family F (with FYVE domain) member 2

GeneMGI:1919051Synonyms: ZFYVE18, 1110070J07Rik

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hearing/vestibular/ear Hematopoietic system Behavior/neurological Renal/urinary system

15 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal auditory brainstem response	2 supporting datasets	Plekhf2^{em1(IMPC)Wtsi}	homozygote	Early adult	2.53x10^-8
increased circulating unsaturated transferrin level	1 supporting dataset	Plekhf2^{em1(IMPC)Wtsi}	homozygote	Early adult	2.42x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Plekhf2^{em1(IMPC)Wtsi}	homozygote	Early adult	6.52x10^-6
decreased mean corpuscular hemoglobin	1 supporting dataset	Plekhf2^{em1(IMPC)Wtsi}	homozygote	Early adult	3.39x10^-15
increased eosinophil cell number	1 supporting dataset	Plekhf2^{em1(IMPC)Wtsi}	homozygote	Early adult	8.61x10^-5
decreased circulating HDL cholesterol level	1 supporting dataset	Plekhf2^{em1(IMPC)Wtsi}	homozygote	Early adult	3.96x10^-5
decreased circulating cholesterol level	1 supporting dataset	Plekhf2^{em1(IMPC)Wtsi}	homozygote	Early adult	3.49x10^-5
decreased mean corpuscular volume	1 supporting dataset	Plekhf2^{em1(IMPC)Wtsi}	homozygote	Early adult	3.85x10^-19
small kidney	1 supporting dataset	Plekhf2^{em1(IMPC)Wtsi}	homozygote	Early adult	N/A ^*
decreased startle reflex	1 supporting dataset	Plekhf2^{em1(IMPC)Wtsi}	homozygote	Early adult	3.43x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Plekhf2.

Associated images

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Histopathology

There is no histopathology data found for Plekhf2.

IMPC related publications

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External links

No external links available for Plekhf2.

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*Plekhf2^{em1(IMPC)Wtsi}*	Deletion	‌	mouse
*Plekhf2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Plekhf2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Plekhf2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Plekhf2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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