Ints12 | integrator complex subunit 12
Physiological systems
21 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Hematopoietic system Mortality/aging
17 No significant impact
3 Not tested
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:50Adult tissues
21Embryo tissues
| decreased red blood cell distribution width | 1 supporting dataset | Ints12tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.23x10-6 | ||
| preweaning lethality, complete penetrance | 2 supporting datasets | Ints12tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased lean body mass | 1 supporting dataset | Ints12tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.18x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Ints12tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating creatine kinase level | 1 supporting dataset | Ints12tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 7.81x10-11 | ||
| increased circulating triglyceride level | 1 supporting dataset | Ints12tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.2x10-5 | ||
| increased circulating magnesium level | 1 supporting dataset | Ints12tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 3.26x10-6 |
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External links
No external links available for Ints12.
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| Ints12tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ints12tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ints12tm1c(EUCOMM)Wtsi | Wild type floxed exon (post-Flp) | | mouse |
| Ints12tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |