Ints12 | integrator complex subunit 12
Physiological systems
21 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Hematopoietic system Mortality/aging
17 No significant impact
3 Not tested
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:50Adult tissues
21Embryo tissues
| decreased red blood cell distribution width | 1 supporting dataset | Ints12tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.23x10-6 | ||
| preweaning lethality, complete penetrance | 2 supporting datasets | Ints12tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased lean body mass | 1 supporting dataset | Ints12tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.18x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Ints12tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating creatine kinase level | 1 supporting dataset | Ints12tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 7.81x10-11 | ||
| increased circulating triglyceride level | 1 supporting dataset | Ints12tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.2x10-5 | ||
| increased circulating magnesium level | 1 supporting dataset | Ints12tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 3.26x10-6 |
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| adrenal gland | heterozygote | n/a | 100% (4/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/4) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (4/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (4/4) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
Human diseases caused by Ints12 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ints12.
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| Ints12tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Ints12tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Ints12tm1c(EUCOMM)Wtsi | Wild type floxed exon (post-Flp) | | mouse |
| Ints12tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |