Klhl5 | kelch-like 5
Physiological systems
21 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Integument Vision/eye Skeleton Renal/urinary system
15 No significant impact
3 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:78Adult tissues
27Embryo tissues
| abnormal coat/hair pigmentation | 3 supporting datasets | Klhl5tm1b(EUCOMM)Hmgu | homozygote | Early adult | 6.47x10-10 | ||
| abnormal lens morphology | 1 supporting dataset | Klhl5tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.17x10-5 | ||
| abnormal rib morphology | 1 supporting dataset | Klhl5tm1b(EUCOMM)Hmgu | homozygote | Early adult | 2.11x10-5 | ||
| abnormal cornea morphology | 1 supporting dataset | Klhl5tm1b(EUCOMM)Hmgu | homozygote | Early adult | 1.45x10-6 | ||
| abnormal kidney morphology | 1 supporting dataset | Klhl5tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| increased circulating triglyceride level | 1 supporting dataset | Klhl5tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.57x10-6 |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | n/a | 0% (0/17) |
| bone | heterozygote | n/a | 50% (1/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | n/a | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 50% (1/2) | 7.75% (22/284) |
Human diseases caused by Klhl5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Klhl5.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Klhl5tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Klhl5tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Klhl5tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |