Ap2b1 | adaptor-related protein complex 2, beta 1 subunit
Physiological systems
19 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Embryo Growth/size/body region Digestive/alimentary Behavior/neurological Craniofacial Mortality/aging
13 No significant impact
5 Not tested
Data collections
Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| cleft palate | 1 supporting dataset | Ap2b1em1(IMPC)J | homozygote | E18.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Ap2b1em1(IMPC)J | homozygote | Early adult | N/A * | ||
| decreased grip strength | 1 supporting dataset | Ap2b1em1(IMPC)J | heterozygote | Early adult | 7.91x10-5 | ||
| abnormal embryo size | 1 supporting dataset | Ap2b1em1(IMPC)J | homozygote | E18.5 | N/A * |
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Human diseases caused by Ap2b1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ap2b1.
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| Ap2b1em1(IMPC)J | Exon Deletion | | mouse |
| Ap2b1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ap2b1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Ap2b1tm357351(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |