Ipo9 | importin 9
Physiological systems
18 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Limbs/digits/tail Nervous system Mortality/aging Cardiovascular system Craniofacial
10 No significant impact
6 Not tested
Data collections
Gene metrics:17Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal embryo turning | 1 supporting dataset | Ipo9em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Ipo9em1(IMPC)Bay | homozygote | E12.5 | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Ipo9em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Ipo9em1(IMPC)Bay | homozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Ipo9em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal chorioallantoic fusion | 1 supporting dataset | Ipo9em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal pharyngeal arch morphology | 1 supporting dataset | Ipo9em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal embryo development | 1 supporting dataset | Ipo9em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal allantois morphology | 1 supporting dataset | Ipo9em1(IMPC)Bay | homozygote | E9.5 | N/A * | ||
| abnormal hindbrain development | 1 supporting dataset | Ipo9em1(IMPC)Bay | homozygote | E9.5 | N/A * |
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Human diseases caused by Ipo9 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ipo9.
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| Ipo9em1(IMPC)Bay | Exon Deletion | | mouse |
| Ipo9tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ipo9tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Ipo9tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Ipo9tm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |