Tmem248 | transmembrane protein 248

GeneMGI:1918917Synonyms: G430067H08Rik, A930023A16Rik, +1 more

Physiological systems

22 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Adipose tissue Growth/size/body region Digestive/alimentary Liver/biliary system Hematopoietic system Skeleton Cardiovascular system Renal/urinary system

10 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:34Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal pancreas morphology	2 supporting datasets	Tmem248^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
female infertility	1 supporting dataset	Tmem248^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
decreased thymus weight	1 supporting dataset	Tmem248^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	7.22x10^-5
enlarged cecum	2 supporting datasets	Tmem248^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
small seminal vesicle	1 supporting dataset	Tmem248^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
small thymus	1 supporting dataset	Tmem248^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
distended jejunum	2 supporting datasets	Tmem248^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
enlarged duodenum	2 supporting datasets	Tmem248^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
absent pancreas	2 supporting datasets	Tmem248^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Tmem248^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tmem248.

Associated images

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Histopathology

There is no histopathology data found for Tmem248.

IMPC related publications

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External links

No external links available for Tmem248.

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*Tmem248^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Tmem248^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Tmem248^{tm376746(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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