Gimap6 | GTPase, IMAP family member 6

GeneMGI:1918876Synonyms: 4833419H03Rik, Ian6

Physiological systems

18 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system

11 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:22Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

48Embryo tissues

Phenotypes

Allele:

Phy. System:



increased total body fat amount	1 supporting dataset	Gimap6^{tm1a(KOMP)Wtsi}	homozygote	Early adult	3.87x10^-5
increased blood urea nitrogen level	1 supporting dataset	Gimap6^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.87x10^-129
impaired glucose tolerance	1 supporting dataset	Gimap6^{tm1a(KOMP)Wtsi}	homozygote	Early adult	2.31x10^-7
increased fasting circulating glucose level	1 supporting dataset	Gimap6^{tm1b(KOMP)Wtsi}	homozygote	Early adult	3.46x10^-15
decreased memory-marker CD4-negative NK T cell number	1 supporting dataset	Gimap6^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating calcium level	1 supporting dataset	Gimap6^{tm1b(KOMP)Wtsi}	homozygote	Early adult	8.4x10^-6
decreased CD4-negative NK T cell number	1 supporting dataset	Gimap6^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating chloride level	1 supporting dataset	Gimap6^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.64x10^-11
increased circulating sodium level	1 supporting dataset	Gimap6^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.89x10^-5
increased circulating cholesterol level	2 supporting datasets	Gimap6^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.39x10^-39

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gimap6.

Associated images

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Histopathology

There is no histopathology data found for Gimap6.

IMPC related publications

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External links

No external links available for Gimap6.

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*Gimap6^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Gimap6^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Gimap6^{tm45182(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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