Pex1 | peroxisomal biogenesis factor 1

GeneMGI:1918632Synonyms: peroxisome biogenesis factor 1, 5430414H02Rik, +2 more

Physiological systems

18 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Muscle Liver/biliary system Cardiovascular system Mortality/aging

14 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

7Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased cardiac muscle contractility	2 supporting datasets	Pex1^{tm1e.1(EUCOMM)Hmgu}	heterozygote	Early adult	1.03x10^-6
decreased heart rate	1 supporting dataset	Pex1^{tm1e.1(EUCOMM)Hmgu}	heterozygote	Early adult	2.31x10^-8
preweaning lethality, complete penetrance	1 supporting dataset	Pex1^{tm1e.1(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
dilated heart left ventricle	2 supporting datasets	Pex1^{tm1e.1(EUCOMM)Hmgu}	heterozygote	Early adult	2.2x10^-7
abnormal liver morphology	1 supporting dataset	Pex1^{tm1e.1(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pex1.

Associated images

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Histopathology

There is no histopathology data found for Pex1.

IMPC related publications

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External links

No external links available for Pex1.

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*Pex1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Pex1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell mouse
*Pex1^{tm1e.1(EUCOMM)Hmgu}*	Promoter excision from Targeted, non-conditional allele	‌	mouse
*Pex1^{tm46430(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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