Pdss2 | prenyl (solanesyl) diphosphate synthase, subunit 2
Physiological systems
19 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Craniofacial Mortality/aging
10 No significant impact
5 Not tested
Data collections
Gene metrics:11Significant phenotypes
1Associated diseases
Expression examined in:46Adult tissues
21Embryo tissues
| decreased anxiety-related response | 1 supporting dataset | Pdss2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 7.39x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Pdss2tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Pdss2tm1b(EUCOMM)Hmgu | homozygote | E12.5 | N/A * | ||
| thrombocytopenia | 1 supporting dataset | Pdss2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.28x10-6 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Pdss2tm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * | ||
| increased total body fat amount | 1 supporting dataset | Pdss2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.82x10-5 | ||
| vertebral fusion | 1 supporting dataset | Pdss2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 2x10-6 | ||
| abnormal tooth morphology | 1 supporting dataset | Pdss2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 8.77x10-9 | ||
| decreased thigmotaxis | 1 supporting dataset | Pdss2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.1x10-6 | ||
| cataract | 1 supporting dataset | Pdss2tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 8.62x10-5 |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Pdss2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Pdss2.
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| Pdss2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Pdss2tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Pdss2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |