Pdss2 | prenyl (solanesyl) diphosphate synthase, subunit 2

GeneMGI:1918615Synonyms: PLMP, 5430420P03Rik, +2 more

Physiological systems

19 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Craniofacial Mortality/aging

10 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

1Associated diseases

Expression examined in:46Adult tissues

21Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased anxiety-related response	1 supporting dataset	Pdss2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.39x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Pdss2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Pdss2^{tm1b(EUCOMM)Hmgu}	homozygote	E12.5	N/A ^*
thrombocytopenia	1 supporting dataset	Pdss2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.28x10^-6
embryonic lethality prior to organogenesis	1 supporting dataset	Pdss2^{tm1b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
increased total body fat amount	1 supporting dataset	Pdss2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.82x10^-5
vertebral fusion	1 supporting dataset	Pdss2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2x10^-6
abnormal tooth morphology	1 supporting dataset	Pdss2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8.77x10^-9
decreased thigmotaxis	1 supporting dataset	Pdss2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.1x10^-6
cataract	1 supporting dataset	Pdss2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	8.62x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pdss2.

Associated images

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Histopathology

There is no histopathology data found for Pdss2.

IMPC related publications

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External links

No external links available for Pdss2.

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*Pdss2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pdss2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pdss2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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