Rnf148 | ring finger protein 148

GeneMGI:1918550Synonyms: 4933432M07Rik, Greul3

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Hematopoietic system Behavior/neurological Skeleton

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



kyphosis	1 supporting dataset	Rnf148^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.05x10^-5
decreased locomotor activity	1 supporting dataset	Rnf148^{em1(IMPC)Ccpcz}	homozygote	Early adult	9.1x10^-8
decreased thigmotaxis	2 supporting datasets	Rnf148^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.34x10^-7
cryptorchism	1 supporting dataset	Rnf148^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Rnf148^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Rnf148^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Rnf148^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
hyperactivity	1 supporting dataset	Rnf148^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.14x10^-7
decreased circulating serum albumin level	1 supporting dataset	Rnf148^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.4x10^-6
abnormal spine curvature	1 supporting dataset	Rnf148^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.64x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rnf148.

Associated images

16 images

X-ray

XRay Images Forepaw

32 images

X-ray

XRay Images Hind Leg and Hip

16 images

X-ray

XRay Images Skull Dorso Ventral Orientation

16 images

X-ray

XRay Images Skull Lateral Orientation

32 images

X-ray

XRay Images Whole Body Dorso Ventral

16 images

X-ray

XRay Images Whole Body Lateral Orientation

Human diseases caused by Rnf148 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.



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Histopathology

There is no histopathology data found for Rnf148.

IMPC related publications

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External links

No external links available for Rnf148.

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*Rnf148^{em1(IMPC)Ccpcz}*	Intra-exon deletion	‌	mouse
*Rnf148^{tm378004(Ifitm2_intron_L1L2_GT1_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes

Rnf148 | ring finger protein 148

Physiological systems

7 Significantly impacted by the knock-out

14 No significant impact

3 Not tested

Data collections

Phenotypes

lacZ Expression

Associated images

X-ray

X-ray

X-ray

X-ray

X-ray

X-ray

Human diseases caused by Rnf148 mutations

Histopathology

IMPC related publications

External links

Order Mouse and ES Cells

The IMPC Newsletter

Access Data Release 22.1 Data