Rimklb | ribosomal modification protein rimK-like family member B
Physiological systems
18 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Reproductive system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Cardiovascular system
11 No significant impact
6 Not tested
Data collections
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| hyperactivity | 9 supporting datasets | Rimklbtm1.1(KOMP)Vlcg | homozygote | Early adult | 1.7x10-13 | ||
| increased grip strength | 2 supporting datasets | Rimklbtm1.1(KOMP)Vlcg | homozygote | Late adult | 9.82x10-11 | ||
| hyperactivity | 8 supporting datasets | Rimklbtm1.1(KOMP)Vlcg | homozygote | Late adult | 2.34x10-9 | ||
| increased heart weight | 1 supporting dataset | Rimklbtm1.1(KOMP)Vlcg | homozygote | Early adult | 1.95x10-5 | ||
| abnormal sleep behavior | 2 supporting datasets | Rimklbtm1.1(KOMP)Vlcg | homozygote | Early adult | 2.1x10-6 | ||
| increased exploration in new environment | 1 supporting dataset | Rimklbtm1.1(KOMP)Vlcg | homozygote | Late adult | 5.46x10-6 | ||
| increased bone mineral content | 1 supporting dataset | Rimklbtm1.1(KOMP)Vlcg | homozygote | Late adult | 2.99x10-5 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Rimklbtm1.1(KOMP)Vlcg | homozygote | Early adult | 6.61x10-5 | ||
| decreased total body fat amount | 1 supporting dataset | Rimklbtm1.1(KOMP)Vlcg | homozygote | Late adult | 8.87x10-6 | ||
| male infertility | 1 supporting dataset | Rimklbtm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Rimklb mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Rimklb.
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| Rimklbtm1(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Rimklbtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Rimklbtm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Rimklbtm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Rimklbtm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |