Prss54 | serine protease 54
Physiological systems
21 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Immune system Endocrine/exocrine gland Integument Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Cardiovascular system
13 No significant impact
3 Not tested
Data collections
Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged thymus | 1 supporting dataset | Prss54em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal skin morphology | 1 supporting dataset | Prss54em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal thymus morphology | 1 supporting dataset | Prss54em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| kyphosis | 1 supporting dataset | Prss54em1(IMPC)Ccpcz | homozygote | Early adult | 9.72x10-6 | ||
| decreased memory-marker CD4-positive NK T cell number | 1 supporting dataset | Prss54em1(IMPC)Ccpcz | homozygote | Early adult | 1.45x10-5 | ||
| decreased NK T cell number | 1 supporting dataset | Prss54em1(IMPC)Ccpcz | homozygote | Early adult | 7.64x10-6 | ||
| abnormal spine curvature | 1 supporting dataset | Prss54em1(IMPC)Ccpcz | homozygote | Early adult | 1.85x10-5 | ||
| decreased startle reflex | 1 supporting dataset | Prss54em1(IMPC)Ccpcz | homozygote | Early adult | 8x10-6 | ||
| decreased CD4-positive NK T cell number | 1 supporting dataset | Prss54em1(IMPC)Ccpcz | homozygote | Early adult | 1.39x10-5 | ||
| abnormal heart morphology | 1 supporting dataset | Prss54em1(IMPC)Ccpcz | homozygote | Early adult | N/A * |
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Human diseases caused by Prss54 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Prss54.
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| Prss54em1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Prss54tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Prss54tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |