Clic5 | chloride intracellular channel 5
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Nervous system Behavior/neurological Skeleton
15 No significant impact
6 Not tested
Data collections
Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:50Adult tissues
0Embryo tissues
| decreased bone mineral density | 1 supporting dataset | Clic5tm1b(EUCOMM)Hmgu | homozygote | Early adult | 8.66x10-5 | ||
| decreased prepulse inhibition | 4 supporting datasets | Clic5tm1b(EUCOMM)Hmgu | homozygote | Early adult | 4.39x10-30 | ||
| decreased startle reflex | 1 supporting dataset | Clic5tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.21x10-5 | ||
| head bobbing | 1 supporting dataset | Clic5tm1b(EUCOMM)Hmgu | homozygote | Early adult | 7.67x10-10 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | Wholemount images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Wholemount images | 100% (2/2) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/2) | 1.67% (7/419) |
Human diseases caused by Clic5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Clic5.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Clic5tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Clic5tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Clic5tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Clic5tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Clic5tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |