Sugp1 | SURP and G patch domain containing 1

GeneMGI:1917866Synonyms: Sf4

Physiological systems

22 / 24 physiological systems tested

11 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Embryo Growth/size/body region Liver/biliary system Hematopoietic system Behavior/neurological Mortality/aging Renal/urinary system

11 No significant impact

2 Not tested

Gene metrics:19Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

enlarged kidney1 supporting datasetSugp1em1(IMPC)MbpheterozygoteLate adultN/A * 
abnormal lymph node morphology1 supporting datasetSugp1em1(IMPC)MbpheterozygoteLate adultN/A * 
abnormal ovary morphology1 supporting datasetSugp1em1(IMPC)MbpheterozygoteLate adultN/A * 
enlarged spleen2 supporting datasetsSugp1em1(IMPC)MbpheterozygoteLate adultN/A * 
preweaning lethality, incomplete penetrance3 supporting datasetsSugp1em1(IMPC)MbphomozygoteEarly adultN/A * 
abnormal liver morphology2 supporting datasetsSugp1em1(IMPC)MbpheterozygoteLate adultN/A * 
abnormal uterus morphology1 supporting datasetSugp1em1(IMPC)MbpheterozygoteLate adultN/A * 
abnormal spleen morphology2 supporting datasetsSugp1em1(IMPC)MbpheterozygoteLate adultN/A * 
abnormal freezing behavior1 supporting datasetSugp1em1(IMPC)MbpheterozygoteEarly adult7.12x10-7 
no spontaneous movement1 supporting datasetSugp1em1(IMPC)MbpheterozygoteE18.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Sugp1em1(IMPC)MbpExon Deletionmouse
Sugp1tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Sugp1tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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