Secisbp2l | SECIS binding protein 2-like
Physiological systems
17 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Growth/size/body region Limbs/digits/tail Hearing/vestibular/ear Behavior/neurological Skeleton Cardiovascular system
9 No significant impact
7 Not tested
Data collections
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased startle reflex | 1 supporting dataset | Secisbp2lem1(IMPC)J | homozygote | Early adult | 3.27x10-10 | ||
| increased circulating cholesterol level | 1 supporting dataset | Secisbp2lem1(IMPC)J | homozygote | Late adult | 7.08x10-7 | ||
| decreased total body fat amount | 1 supporting dataset | Secisbp2lem1(IMPC)J | homozygote | Late adult | 1.49x10-6 | ||
| increased lean body mass | 2 supporting datasets | Secisbp2lem1(IMPC)J | homozygote | Late adult | 6.57x10-8 | ||
| increased aggression | 1 supporting dataset | Secisbp2lem1(IMPC)J | homozygote | Early adult | 4.37x10-5 | ||
| increased bone mineral content | 1 supporting dataset | Secisbp2lem1(IMPC)J | homozygote | Late adult | 2.64x10-6 | ||
| increased heart rate | 1 supporting dataset | Secisbp2lem1(IMPC)J | homozygote | Late adult | 2.26x10-7 | ||
| decreased circulating aspartate transaminase level | 1 supporting dataset | Secisbp2lem1(IMPC)J | homozygote | Late adult | 1.13x10-7 | ||
| increased grip strength | 1 supporting dataset | Secisbp2lem1(IMPC)J | homozygote | Late adult | 3.86x10-6 | ||
| abnormal hindlimb morphology | 1 supporting dataset | Secisbp2lem1(IMPC)J | homozygote | Late adult | 1.51x10-5 |
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Human diseases caused by Secisbp2l mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Secisbp2l.
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| Secisbp2lem1(IMPC)J | Exon Deletion | | mouse |
| Secisbp2ltm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Secisbp2ltm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |