Polr1g | RNA polymerase I subunit G

GeneMGI:1917583Synonyms: PAF49, Ase1, +2 more

Physiological systems

20 / 24 physiological systems tested

1 Significantly impacted by the knock-out

 Mortality/aging

19 No significant impact

4 Not tested

Gene metrics:2Significant phenotypes
0Associated diseases
Expression examined in:51Adult tissues
62Embryo tissues

Phenotypes

embryonic lethality prior to organogenesis1 supporting datasetPolr1gtm1b(KOMP)WtsihomozygoteE9.5N/A * 
preweaning lethality, complete penetrance3 supporting datasetsPolr1gtm1b(KOMP)WtsihomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoteWholemount images
100% (2/2)0.7% (4/570)
aortaheterozygoteWholemount images
n/a0.19% (1/533)
boneheterozygoteWholemount images
n/a0% (0/394)
brainheterozygoteWholemount images
100% (2/2)0.86% (5/579)
brainstemheterozygoteWholemount images
100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoteWholemount images
100% (2/2)0.22% (1/454)
cecumheterozygoten/a100% (1/1)7.75% (22/284)
cerebellumheterozygoteWholemount images
100% (2/2)0.56% (3/532)
cerebral cortexheterozygoteWholemount images
100% (2/2)0.41% (2/491)
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Histopathology

IMPC related publications

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Polr1gtm115411(L1L2_Pgk_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Polr1gtm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Polr1gtm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Polr1gtm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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