Hdac8 | histone deacetylase 8

GeneMGI:1917565Synonyms: 2610007D20Rik

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Skeleton

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

3Associated diseases

Expression examined in:90Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased circulating magnesium level	1 supporting dataset	Hdac8^{tm1a(EUCOMM)Wtsi}	hemizygote	Early adult	2.64x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Hdac8^{tm1a(EUCOMM)Wtsi}	hemizygote	Early adult	9.02x10^-7
decreased bone mineral density	1 supporting dataset	Hdac8^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.87x10^-8
decreased bone mineral content	1 supporting dataset	Hdac8^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.3x10^-9
increased circulating aspartate transaminase level	1 supporting dataset	Hdac8^{tm1a(EUCOMM)Wtsi}	hemizygote	Early adult	2.22x10^-5
decreased bone mineral density	1 supporting dataset	Hdac8^{tm1a(EUCOMM)Wtsi}	hemizygote	Early adult	4.33x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Hdac8^{tm1a(EUCOMM)Wtsi}	hemizygote	Early adult	3.63x10^-5
decreased body length	1 supporting dataset	Hdac8^{tm1a(EUCOMM)Wtsi}	hemizygote	Early adult	1.5x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hdac8.

Associated images

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Histopathology

There is no histopathology data found for Hdac8.

IMPC related publications

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External links

No external links available for Hdac8.

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*Hdac8^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Hdac8^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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