Hdac8 | histone deacetylase 8
Physiological systems
20 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Skeleton
17 No significant impact
4 Not tested
Data collections
Gene metrics:7Significant phenotypes
3Associated diseases
Expression examined in:90Adult tissues
0Embryo tissues
| increased circulating magnesium level | 1 supporting dataset | Hdac8tm1a(EUCOMM)Wtsi | hemizygote | Early adult | 2.64x10-5 | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Hdac8tm1a(EUCOMM)Wtsi | hemizygote | Early adult | 9.02x10-7 | ||
| decreased bone mineral density | 1 supporting dataset | Hdac8tm1a(EUCOMM)Wtsi | homozygote | Early adult | 8.87x10-8 | ||
| decreased bone mineral content | 1 supporting dataset | Hdac8tm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.3x10-9 | ||
| increased circulating aspartate transaminase level | 1 supporting dataset | Hdac8tm1a(EUCOMM)Wtsi | hemizygote | Early adult | 2.22x10-5 | ||
| decreased bone mineral density | 1 supporting dataset | Hdac8tm1a(EUCOMM)Wtsi | hemizygote | Early adult | 4.33x10-5 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Hdac8tm1a(EUCOMM)Wtsi | hemizygote | Early adult | 3.63x10-5 | ||
| decreased body length | 1 supporting dataset | Hdac8tm1a(EUCOMM)Wtsi | hemizygote | Early adult | 1.5x10-5 |
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| adrenal gland | heterozygote | n/a | 0% (0/1) | 0.7% (4/570) |
| adrenal gland | hemizygote | n/a | 100% (1/1) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| aorta | hemizygote | n/a | 0% (0/1) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/1) | 0% (0/173) |
| blood vessel | hemizygote | n/a | 0% (0/1) | 0% (0/173) |
| bone | hemizygote | n/a | 0% (0/1) | 0% (0/394) |
| bone | heterozygote | n/a | 0% (0/1) | 0% (0/394) |
| brain | hemizygote | n/a | 100% (1/1) | 0.86% (5/579) |
| brain | heterozygote | n/a | 100% (1/1) | 0.86% (5/579) |
Human diseases caused by Hdac8 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Hdac8.
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| Hdac8tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Hdac8tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |