Hdac8 | histone deacetylase 8

GeneMGI:1917565Synonyms: 2610007D20Rik

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Skeleton

17 No significant impact

4 Not tested

Gene metrics:7Significant phenotypes
3Associated diseases
Expression examined in:90Adult tissues
0Embryo tissues

Phenotypes

increased circulating magnesium level1 supporting datasetHdac8tm1a(EUCOMM)WtsihemizygoteEarly adult2.64x10-5 
increased circulating alanine transaminase level1 supporting datasetHdac8tm1a(EUCOMM)WtsihemizygoteEarly adult9.02x10-7 
decreased bone mineral density1 supporting datasetHdac8tm1a(EUCOMM)WtsihomozygoteEarly adult8.87x10-8 
decreased bone mineral content1 supporting datasetHdac8tm1a(EUCOMM)WtsihomozygoteEarly adult2.3x10-9 
increased circulating aspartate transaminase level1 supporting datasetHdac8tm1a(EUCOMM)WtsihemizygoteEarly adult2.22x10-5 
decreased bone mineral density1 supporting datasetHdac8tm1a(EUCOMM)WtsihemizygoteEarly adult4.33x10-5 
increased circulating alkaline phosphatase level1 supporting datasetHdac8tm1a(EUCOMM)WtsihemizygoteEarly adult3.63x10-5 
decreased body length1 supporting datasetHdac8tm1a(EUCOMM)WtsihemizygoteEarly adult1.5x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/1)0.7% (4/570)
adrenal glandhemizygoten/a100% (1/1)0.7% (4/570)
aortaheterozygoten/an/a0.19% (1/533)
aortahemizygoten/a0% (0/1)0.19% (1/533)
blood vesselheterozygoten/a0% (0/1)0% (0/173)
blood vesselhemizygoten/a0% (0/1)0% (0/173)
bonehemizygoten/a0% (0/1)0% (0/394)
boneheterozygoten/a0% (0/1)0% (0/394)
brainhemizygoten/a100% (1/1)0.86% (5/579)
brainheterozygoten/a100% (1/1)0.86% (5/579)
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Associated images

Human diseases caused by Hdac8 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.






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Histopathology

IMPC related publications

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Hdac8tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Hdac8tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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