Fuz | fuzzy planar cell polarity protein
Physiological systems
22 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Digestive/alimentary Limbs/digits/tail Vision/eye Nervous system Craniofacial Mortality/aging Cardiovascular system
12 No significant impact
2 Not tested
Data collections
Gene metrics:20Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| syndactyly | 1 supporting dataset | Fuzem1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Fuzem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal tail morphology | 1 supporting dataset | Fuzem1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| edema | 1 supporting dataset | Fuzem1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| abnormal craniofacial morphology | 1 supporting dataset | Fuzem1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| hemorrhage | 1 supporting dataset | Fuzem1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| cleft palate | 1 supporting dataset | Fuzem1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| anophthalmia | 1 supporting dataset | Fuzem1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| polydactyly | 1 supporting dataset | Fuzem1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| abnormal neural tube morphology | 1 supporting dataset | Fuzem1(IMPC)Mbp | homozygote | E9.5 | N/A * |
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Human diseases caused by Fuz mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Fuz.
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| Fuzem1(IMPC)Mbp | Exon Deletion | | mouse |
| Fuztm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Fuztm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |