Dazap1 | DAZ associated protein 1
Physiological systems
24 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Immune system Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system Mortality/aging
17 No significant impact
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| enlarged heart | 1 supporting dataset | Dazap1em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| decreased total body fat amount | 2 supporting datasets | Dazap1em1(IMPC)Ccpcz | heterozygote | Early adult | 8.88x10-6 | ||
| increased lean body mass | 2 supporting datasets | Dazap1em1(IMPC)Ccpcz | heterozygote | Early adult | 1.51x10-11 | ||
| abnormal heart morphology | 1 supporting dataset | Dazap1em1(IMPC)Ccpcz | heterozygote | Early adult | N/A * | ||
| no spontaneous movement | 1 supporting dataset | Dazap1em1(IMPC)Ccpcz | homozygote | E18.5 | N/A * | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Dazap1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased eosinophil cell number | 1 supporting dataset | Dazap1em1(IMPC)Ccpcz | heterozygote | Early adult | 1.66x10-5 | ||
| decreased locomotor activity | 1 supporting dataset | Dazap1em1(IMPC)Ccpcz | heterozygote | Early adult | 8.63x10-5 |
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Human diseases caused by Dazap1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dazap1.
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| Dazap1em1(IMPC)Ccpcz | Inter-exon deletion | | mouse |
| Dazap1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Dazap1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |