Rnf168 | ring finger protein 168

GeneMGI:1917488Synonyms: 3110001H15Rik

Physiological systems

21 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Pigmentation Integument Endocrine/exocrine gland Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Craniofacial

9 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:31Significant phenotypes

2Associated diseases

Expression examined in:78Adult tissues

27Embryo tissues

Phenotypes

Allele:

Phy. System:



abnormal thymus morphology	2 supporting datasets	Rnf168^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased grip strength	2 supporting datasets	Rnf168^em1(IMPC)H	homozygote	Early adult	5.35x10^-6
cornea opacity	1 supporting dataset	Rnf168^em1(IMPC)H	homozygote	Early adult	2.56x10^-5
increased mean platelet volume	1 supporting dataset	Rnf168^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	9.35x10^-7
abnormal skin morphology	2 supporting datasets	Rnf168^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal heart morphology	1 supporting dataset	Rnf168^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased grip strength	1 supporting dataset	Rnf168^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	7.79x10^-5
abnormal eye morphology	2 supporting datasets	Rnf168^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased body weight	1 supporting dataset	Rnf168^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	1.1x10^-18
anophthalmia	2 supporting datasets	Rnf168^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rnf168.

Associated images

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Histopathology

There is no histopathology data found for Rnf168.

IMPC related publications

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External links

No external links available for Rnf168.

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*Rnf168^em1(IMPC)H*	Exon Deletion	‌	mouse
*Rnf168^em2(IMPC)H*	Exon Deletion	‌	mouse
*Rnf168^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Rnf168^{tm2b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Rnf168^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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