Med23 | mediator complex subunit 23
Physiological systems
20 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Hematopoietic system Skeleton Mortality/aging
15 No significant impact
4 Not tested
Data collections
Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 1 supporting dataset | Med23em1(IMPC)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Med23em1(IMPC)Wtsi | heterozygote | Early adult | 1.22x10-8 | ||
| increased red blood cell distribution width | 1 supporting dataset | Med23em1(IMPC)Wtsi | heterozygote | Early adult | 6.69x10-5 | ||
| increased lean body mass | 1 supporting dataset | Med23em1(IMPC)Wtsi | heterozygote | Early adult | 2.71x10-5 | ||
| decreased bone mineral content | 1 supporting dataset | Med23em1(IMPC)Wtsi | heterozygote | Early adult | 6.37x10-5 | ||
| decreased circulating fructosamine level | 1 supporting dataset | Med23em1(IMPC)Wtsi | heterozygote | Early adult | 1.56x10-5 |
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Human diseases caused by Med23 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Med23.
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| Med23em1(IMPC)Wtsi | Deletion | | mouse |
| Med23tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Med23tm1aIcs | KO first allele (reporter-tagged insertion with conditional potential) | | ES Cell mouse |
| Med23tm1dIcs | Deletion allele (post-Flp and Cre with no reporter) | | mouse |
| Med23tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Med23tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |