Med23 | mediator complex subunit 23

GeneMGI:1917458Synonyms: sno, Crsp3, +4 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Hematopoietic system Skeleton Mortality/aging

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Med23^{em1(IMPC)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating HDL cholesterol level	1 supporting dataset	Med23^{em1(IMPC)Wtsi}	heterozygote	Early adult	1.22x10^-8
increased red blood cell distribution width	1 supporting dataset	Med23^{em1(IMPC)Wtsi}	heterozygote	Early adult	6.69x10^-5
increased lean body mass	1 supporting dataset	Med23^{em1(IMPC)Wtsi}	heterozygote	Early adult	2.71x10^-5
decreased bone mineral content	1 supporting dataset	Med23^{em1(IMPC)Wtsi}	heterozygote	Early adult	6.37x10^-5
decreased circulating fructosamine level	1 supporting dataset	Med23^{em1(IMPC)Wtsi}	heterozygote	Early adult	1.56x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Med23.

Associated images

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Histopathology

There is no histopathology data found for Med23.

IMPC related publications

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External links

No external links available for Med23.

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*Med23^{em1(IMPC)Wtsi}*	Deletion	‌	mouse
*Med23^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Med23^tm1aIcs*	KO first allele (reporter-tagged insertion with conditional potential)	‌	es cell mouse
*Med23^tm1dIcs*	Deletion allele (post-Flp and Cre with no reporter)	‌	mouse
*Med23^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Med23^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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