Mllt3 | myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
Physiological systems
18 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Vision/eye Hematopoietic system Behavior/neurological Skeleton Mortality/aging Renal/urinary system
10 No significant impact
6 Not tested
Gene metrics:8Significant phenotypes
1Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
| thrombocytopenia | 1 supporting dataset | Mllt3tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 1.3x10-8 | ||
| decreased kidney weight | 2 supporting datasets | Mllt3tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 9.8x10-7 | ||
| cataract | 1 supporting dataset | Mllt3tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.91x10-6 | ||
| hyperactivity | 1 supporting dataset | Mllt3tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 4.42x10-5 | ||
| increased total body fat amount | 1 supporting dataset | Mllt3tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.48x10-5 | ||
| increased circulating amylase level | 1 supporting dataset | Mllt3tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 3.87x10-7 | ||
| abnormal clavicle morphology | 1 supporting dataset | Mllt3tm1b(EUCOMM)Hmgu | heterozygote | Early adult | 5.31x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Mllt3tm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * |
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| adrenal gland | heterozygote | n/a | 0% (0/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/4) | 0.19% (1/533) |
| bone | heterozygote | n/a | 0% (0/4) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (4/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 75% (3/4) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/4) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (4/4) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 75% (3/4) | 0.41% (2/491) |
| esophagus | heterozygote | n/a | 0% (0/4) | 1.67% (7/419) |
Human diseases caused by Mllt3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mllt3.
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| Mllt3tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Mllt3tm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Mllt3tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |