Mllt3 | myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3

GeneMGI:1917372Synonyms: 3830408D16Rik, 2610012I03Rik, +3 more

Physiological systems

18 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Vision/eye Hematopoietic system Behavior/neurological Skeleton Mortality/aging Renal/urinary system

10 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

1Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



thrombocytopenia	1 supporting dataset	Mllt3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.3x10^-8
decreased kidney weight	2 supporting datasets	Mllt3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	9.8x10^-7
cataract	1 supporting dataset	Mllt3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.91x10^-6
hyperactivity	1 supporting dataset	Mllt3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.42x10^-5
increased total body fat amount	1 supporting dataset	Mllt3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.48x10^-5
increased circulating amylase level	1 supporting dataset	Mllt3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.87x10^-7
abnormal clavicle morphology	1 supporting dataset	Mllt3^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.31x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Mllt3^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mllt3.

Associated images

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Histopathology

There is no histopathology data found for Mllt3.

IMPC related publications

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External links

No external links available for Mllt3.

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*Mllt3^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Mllt3^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Mllt3^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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