Dnmbp | dynamin binding protein

GeneMGI:1917352Synonyms: Tuba, 2410003M15Rik, +1 more

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Immune system Integument Growth/size/body region Hearing/vestibular/ear Nervous system Liver/biliary system Hematopoietic system Behavior/neurological Renal/urinary system

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



abnormal skin morphology	2 supporting datasets	Dnmbp^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal spleen morphology	1 supporting dataset	Dnmbp^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Dnmbp^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
increased vertical activity	1 supporting dataset	Dnmbp^em1(IMPC)Mbp	homozygote	Early adult	2.67x10^-6
enlarged spleen	1 supporting dataset	Dnmbp^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
increased prepulse inhibition	4 supporting datasets	Dnmbp^em1(IMPC)Mbp	homozygote	Early adult	7.69x10^-7
abnormal liver morphology	1 supporting dataset	Dnmbp^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
small kidney	1 supporting dataset	Dnmbp^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
decreased startle reflex	1 supporting dataset	Dnmbp^em1(IMPC)Mbp	homozygote	Early adult	9.32x10^-5
abnormal auditory brainstem response	1 supporting dataset	Dnmbp^em1(IMPC)Mbp	homozygote	Early adult	1.83x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dnmbp.

Associated images

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Histopathology

There is no histopathology data found for Dnmbp.

IMPC related publications

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External links

No external links available for Dnmbp.

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*Dnmbp^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Dnmbp^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Dnmbp^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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