Rab28 | RAB28, member RAS oncogene family

GeneMGI:1917285Synonyms: 2700023P08Rik

Physiological systems

17 / 24 physiological systems tested

8 Significantly impacted by the knock-out

 Homeostasis/metabolism Pigmentation Integument Adipose tissue Growth/size/body region Behavior/neurological Skeleton Cardiovascular system

9 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:10Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased lean body mass2 supporting datasetsRab28em1(IMPC)JhomozygoteEarly adult2.04x10-7 
decreased circulating total protein level1 supporting datasetRab28em1(IMPC)JhomozygoteEarly adult6.79x10-5 
decreased bone mineral content2 supporting datasetsRab28em1(IMPC)JhomozygoteEarly adult1.21x10-16 
abnormal vocalization1 supporting datasetRab28em1(IMPC)JhomozygoteEarly adult9.21x10-7 
abnormal bone structure1 supporting datasetRab28em1(IMPC)JhomozygoteEarly adult4.49x10-17 
decreased heart weight1 supporting datasetRab28em1(IMPC)JhomozygoteEarly adult1.83x10-5 
increased circulating triglyceride level1 supporting datasetRab28em1(IMPC)JhomozygoteEarly adult1.3x10-6 
abnormal coat/hair pigmentation1 supporting datasetRab28em1(IMPC)JhomozygoteEarly adult7.02x10-8 
decreased bone mineral density1 supporting datasetRab28em1(IMPC)JhomozygoteEarly adult1.67x10-6 
increased total body fat amount2 supporting datasetsRab28em1(IMPC)JhomozygoteEarly adult1.98x10-9 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Rab28em1(IMPC)JExon Deletionmouse
Rab28em2(IMPC)WtsiExon Deletionmouse
Rab28tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Rab28tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell

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