Ace2 | angiotensin converting enzyme 2

GeneMGI:1917258Synonyms: 2010305L05Rik

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Cardiovascular system

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



hydrometra	1 supporting dataset	Ace2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Ace2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased total body fat amount	2 supporting datasets	Ace2^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.18x10^-6
enlarged spleen	1 supporting dataset	Ace2^{em1(IMPC)Ccpcz}	hemizygote	Early adult	N/A ^*
enlarged spleen	1 supporting dataset	Ace2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal uterus morphology	1 supporting dataset	Ace2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal heart morphology	1 supporting dataset	Ace2^{em1(IMPC)Ccpcz}	hemizygote	Early adult	N/A ^*
abnormal retina morphology	1 supporting dataset	Ace2^{em1(IMPC)Ccpcz}	homozygote	Early adult	6.73x10^-8
abnormal lens morphology	1 supporting dataset	Ace2^{em1(IMPC)Ccpcz}	homozygote	Early adult	9.46x10^-5
abnormal thymus morphology	1 supporting dataset	Ace2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ace2.

Associated images

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Histopathology

There is no histopathology data found for Ace2.

IMPC related publications

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External links

No external links available for Ace2.

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*Ace2^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Ace2^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*Ace2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell

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