Ace2 | angiotensin converting enzyme 2
Physiological systems
22 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Reproductive system Immune system Endocrine/exocrine gland Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Cardiovascular system
14 No significant impact
2 Not tested
Data collections
Gene metrics:12Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| hydrometra | 1 supporting dataset | Ace2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| enlarged thymus | 1 supporting dataset | Ace2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| increased total body fat amount | 2 supporting datasets | Ace2em1(IMPC)Ccpcz | homozygote | Early adult | 7.18x10-6 | ||
| enlarged spleen | 1 supporting dataset | Ace2em1(IMPC)Ccpcz | hemizygote | Early adult | N/A * | ||
| enlarged spleen | 1 supporting dataset | Ace2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal uterus morphology | 1 supporting dataset | Ace2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Ace2em1(IMPC)Ccpcz | hemizygote | Early adult | N/A * | ||
| abnormal retina morphology | 1 supporting dataset | Ace2em1(IMPC)Ccpcz | homozygote | Early adult | 6.73x10-8 | ||
| abnormal lens morphology | 1 supporting dataset | Ace2em1(IMPC)Ccpcz | homozygote | Early adult | 9.46x10-5 | ||
| abnormal thymus morphology | 1 supporting dataset | Ace2em1(IMPC)Ccpcz | homozygote | Early adult | N/A * |
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Human diseases caused by Ace2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ace2.
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| Ace2em1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Ace2tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Ace2tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |