Ddi2 | DNA-damage inducible protein 2

GeneMGI:1917244Synonyms: 9130022E05Rik, 1110056G13Rik, +1 more

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Respiratory system Skeleton Mortality/aging Renal/urinary system

16 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:78Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



prenatal lethality prior to heart atrial septation	1 supporting dataset	Ddi2^{tm1b(EUCOMM)Hmgu}	homozygote	E15.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Ddi2^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal spine curvature	1 supporting dataset	Ddi2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.96x10^-6
abnormal urinary bladder morphology	1 supporting dataset	Ddi2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	N/A ^*
increased airway resistance	1 supporting dataset	Ddi2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.81x10^-5
impaired glucose tolerance	1 supporting dataset	Ddi2^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.79x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ddi2.

Associated images

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Histopathology

There is no histopathology data found for Ddi2.

IMPC related publications

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External links

No external links available for Ddi2.

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*Ddi2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ddi2^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ddi2^{tm1c(EUCOMM)Hmgu}*	Wild type floxed exon (post-Flp)	‌	mouse
*Ddi2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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