Mettl18 | methyltransferase like 18

GeneMGI:1917212Synonyms: 2810422O20Rik

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Limbs/digits/tail Behavior/neurological

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

impaired glucose tolerance1 supporting datasetMettl18em1(IMPC)JhomozygoteEarly adult3.95x10-6 
decreased grip strength1 supporting datasetMettl18em1(IMPC)JhomozygoteEarly adult3.7x10-5 
abnormal digit morphology1 supporting datasetMettl18em1(IMPC)JhomozygoteEarly adult1.32x10-6 
increased fasting circulating glucose level1 supporting datasetMettl18em1(IMPC)JhomozygoteEarly adult1.77x10-8 
increased lean body mass1 supporting datasetMettl18em1(IMPC)JhomozygoteEarly adult5.53x10-5 
limb grasping1 supporting datasetMettl18em1(IMPC)JhomozygoteEarly adult7.47x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Mettl18em1(IMPC)JExon Deletionmouse
Mettl18tm1(KOMP)MbpReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell

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