Ppie | peptidylprolyl isomerase E (cyclophilin E)
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Behavior/neurological Mortality/aging
14 No significant impact
6 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| embryonic lethality prior to organogenesis | 1 supporting dataset | Ppieem1(IMPC)Tcp | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Ppieem1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| increased circulating chloride level | 1 supporting dataset | Ppieem1(IMPC)Tcp | heterozygote | Early adult | 2.79x10-5 | ||
| decreased mean corpuscular hemoglobin concentration | 1 supporting dataset | Ppieem1(IMPC)Tcp | heterozygote | Early adult | 3.58x10-5 | ||
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Ppieem1(IMPC)Tcp | heterozygote | Early adult | 2.5x10-11 | ||
| decreased exploration in new environment | 1 supporting dataset | Ppieem1(IMPC)Tcp | heterozygote | Early adult | 1.4x10-6 | ||
| decreased circulating total protein level | 1 supporting dataset | Ppieem1(IMPC)Tcp | heterozygote | Early adult | 8.74x10-7 |
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External links
No external links available for Ppie.
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| Ppieem1(IMPC)Tcp | Exon Deletion | | mouse |
| Ppietm372690(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |