Pcgf1 | polycomb group ring finger 1

GeneMGI:1917087Synonyms: Nspc1, 2010002K04Rik

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Nervous system Vision/eye Behavior/neurological Craniofacial Mortality/aging Cardiovascular system

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

0Associated diseases

Expression examined in:49Adult tissues

29Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal heart morphology	1 supporting dataset	Pcgf1^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
increased vertical activity	1 supporting dataset	Pcgf1^{tm1.1(KOMP)Vlcg}	heterozygote	Late adult	4.8x10^-5
abnormal pharyngeal arch morphology	1 supporting dataset	Pcgf1^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
abnormal embryo turning	1 supporting dataset	Pcgf1^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Pcgf1^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
hyperactivity	1 supporting dataset	Pcgf1^{tm1.1(KOMP)Vlcg}	heterozygote	Late adult	7.83x10^-5
increased fasting circulating glucose level	1 supporting dataset	Pcgf1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	3.9x10^-5
abnormal heart looping	1 supporting dataset	Pcgf1^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
abnormal midbrain development	1 supporting dataset	Pcgf1^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Pcgf1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pcgf1.

Associated images

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Histopathology

There is no histopathology data found for Pcgf1.

IMPC related publications

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External links

No external links available for Pcgf1.

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*Pcgf1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Pcgf1^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Pcgf1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Pcgf1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Pcgf1^{tm447423(Ifitm2_intron_L1L2_GT1_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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