Pcgf1 | polycomb group ring finger 1
Physiological systems
20 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Nervous system Vision/eye Behavior/neurological Craniofacial Mortality/aging Cardiovascular system
11 No significant impact
4 Not tested
Data collections
Gene metrics:15Significant phenotypes
0Associated diseases
Expression examined in:49Adult tissues
29Embryo tissues
| abnormal heart morphology | 1 supporting dataset | Pcgf1tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| increased vertical activity | 1 supporting dataset | Pcgf1tm1.1(KOMP)Vlcg | heterozygote | Late adult | 4.8x10-5 | ||
| abnormal pharyngeal arch morphology | 1 supporting dataset | Pcgf1tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| abnormal embryo turning | 1 supporting dataset | Pcgf1tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Pcgf1tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| hyperactivity | 1 supporting dataset | Pcgf1tm1.1(KOMP)Vlcg | heterozygote | Late adult | 7.83x10-5 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Pcgf1tm1.1(KOMP)Vlcg | heterozygote | Early adult | 3.9x10-5 | ||
| abnormal heart looping | 1 supporting dataset | Pcgf1tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| abnormal midbrain development | 1 supporting dataset | Pcgf1tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Pcgf1tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| bone marrow | heterozygote | Section images | n/a | 0% (0/22) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
Human diseases caused by Pcgf1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Pcgf1.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Pcgf1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Pcgf1tm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Pcgf1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Pcgf1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Pcgf1tm447423(Ifitm2_intron_L1L2_GT1_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |