Paox | polyamine oxidase (exo-N4-amino)

GeneMGI:1916983Synonyms: Pao, 2410012F02Rik

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

13 No significant impact

6 Not tested

Data collections

Viability data
Body weight measurements
Embryo imaging data
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues

Phenotypes

increased circulating aspartate transaminase level1 supporting datasetPaoxtm1.1(KOMP)WtsihomozygoteEarly adult5.74x10-10 
abnormal retina blood vessel morphology1 supporting datasetPaoxtm1.1(KOMP)WtsihomozygoteEarly adult1.17x10-5 
increased heart rate variability1 supporting datasetPaoxtm1.1(KOMP)WtsihomozygoteEarly adult1.08x10-5 
hyperactivity3 supporting datasetsPaoxtm1.1(KOMP)WtsihomozygoteEarly adult9.4x10-6 
thrombocytopenia1 supporting datasetPaoxtm1.1(KOMP)WtsihomozygoteEarly adult1.16x10-6 
abnormal retina vasculature morphology1 supporting datasetPaoxtm1.1(KOMP)WtsihomozygoteEarly adult3.29x10-6 
decreased fasting circulating glucose level1 supporting datasetPaoxtm1.1(KOMP)WtsihomozygoteEarly adult2.41x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Paoxtm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)es cell
Paoxtm1(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)targeting vector
es cell
mouse
Paoxtm1.1(KOMP)WtsiReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Paoxtm106222(L1L2_Pgk_P)Reporter-tagged deletion allele (with selection cassette)targeting vector

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