Paox | polyamine oxidase (exo-N4-amino)
Physiological systems
18 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system
13 No significant impact
6 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues
| increased circulating aspartate transaminase level | 1 supporting dataset | Paoxtm1.1(KOMP)Wtsi | homozygote | Early adult | 5.74x10-10 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Paoxtm1.1(KOMP)Wtsi | homozygote | Early adult | 1.17x10-5 | ||
| increased heart rate variability | 1 supporting dataset | Paoxtm1.1(KOMP)Wtsi | homozygote | Early adult | 1.08x10-5 | ||
| hyperactivity | 3 supporting datasets | Paoxtm1.1(KOMP)Wtsi | homozygote | Early adult | 9.4x10-6 | ||
| thrombocytopenia | 1 supporting dataset | Paoxtm1.1(KOMP)Wtsi | homozygote | Early adult | 1.16x10-6 | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Paoxtm1.1(KOMP)Wtsi | homozygote | Early adult | 3.29x10-6 | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Paoxtm1.1(KOMP)Wtsi | homozygote | Early adult | 2.41x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
Human diseases caused by Paox mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Paox.
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| Paoxtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Paoxtm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell mouse |
| Paoxtm1.1(KOMP)Wtsi | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Paoxtm106222(L1L2_Pgk_P) | Reporter-tagged deletion allele (with selection cassette) | | targeting vector |