Paox | polyamine oxidase (exo-N4-amino)
Physiological systems
18 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system
13 No significant impact
6 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:70Adult tissues
0Embryo tissues
| increased circulating aspartate transaminase level | 1 supporting dataset | Paoxtm1.1(KOMP)Wtsi | homozygote | Early adult | 5.74x10-10 | ||
| abnormal retina blood vessel morphology | 1 supporting dataset | Paoxtm1.1(KOMP)Wtsi | homozygote | Early adult | 1.17x10-5 | ||
| increased heart rate variability | 1 supporting dataset | Paoxtm1.1(KOMP)Wtsi | homozygote | Early adult | 1.08x10-5 | ||
| hyperactivity | 3 supporting datasets | Paoxtm1.1(KOMP)Wtsi | homozygote | Early adult | 9.4x10-6 | ||
| thrombocytopenia | 1 supporting dataset | Paoxtm1.1(KOMP)Wtsi | homozygote | Early adult | 1.16x10-6 | ||
| abnormal retina vasculature morphology | 1 supporting dataset | Paoxtm1.1(KOMP)Wtsi | homozygote | Early adult | 3.29x10-6 | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Paoxtm1.1(KOMP)Wtsi | homozygote | Early adult | 2.41x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 0% (0/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cecum | heterozygote | n/a | 0% (0/2) | 7.75% (22/284) |
External links
No external links available for Paox.
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| Paoxtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
| Paoxtm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell mouse |
| Paoxtm1.1(KOMP)Wtsi | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Paoxtm106222(L1L2_Pgk_P) | Reporter-tagged deletion allele (with selection cassette) | | targeting vector |