Rnaseh2a | ribonuclease H2, large subunit

GeneMGI:1916974Synonyms: 2400006P09Rik

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Hematopoietic system Behavior/neurological Mortality/aging

13 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased monocyte cell number	2 supporting datasets	Rnaseh2a^em1(IMPC)Tcp	heterozygote	Early adult	6.61x10^-16
embryonic lethality prior to tooth bud stage	1 supporting dataset	Rnaseh2a^em1(IMPC)Tcp	homozygote	E12.5	N/A ^*
abnormal ovary morphology	1 supporting dataset	Rnaseh2a^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
thrombocytosis	1 supporting dataset	Rnaseh2a^em1(IMPC)Tcp	heterozygote	Early adult	5.34x10^-6
decreased mean corpuscular hemoglobin	1 supporting dataset	Rnaseh2a^em1(IMPC)Tcp	heterozygote	Early adult	9.88x10^-7
preweaning lethality, complete penetrance	3 supporting datasets	Rnaseh2a^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
decreased mean corpuscular volume	1 supporting dataset	Rnaseh2a^em1(IMPC)Tcp	heterozygote	Early adult	4.14x10^-10
increased spleen weight	1 supporting dataset	Rnaseh2a^em1(IMPC)Tcp	heterozygote	Early adult	1.97x10^-10
increased startle reflex	1 supporting dataset	Rnaseh2a^em1(IMPC)Tcp	heterozygote	Early adult	4.25x10^-5
increased mean platelet volume	1 supporting dataset	Rnaseh2a^em1(IMPC)Tcp	heterozygote	Early adult	2.63x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rnaseh2a.

Associated images

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Histopathology

There is no histopathology data found for Rnaseh2a.

IMPC related publications

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External links

No external links available for Rnaseh2a.

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*Rnaseh2a^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Rnaseh2a^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Rnaseh2a^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Rnaseh2a^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Rnaseh2a^{tm433006(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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