Exosc8 | exosome component 8
Physiological systems
19 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Mortality/aging
16 No significant impact
5 Not tested
Data collections
Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:49Adult tissues
26Embryo tissues
| increased circulating insulin level | 1 supporting dataset | Exosc8tm1.1(KOMP)Vlcg | heterozygote | Early adult | 7.23x10-11 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Exosc8tm1.1(KOMP)Vlcg | homozygote | E12.5 | N/A * | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Exosc8tm1.1(KOMP)Vlcg | heterozygote | Early adult | 2.6x10-6 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Exosc8tm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Exosc8tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
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External links
No external links available for Exosc8.
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| Exosc8tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Exosc8tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Exosc8tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Exosc8tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Exosc8tm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Exosc8tm47080(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |