Dcps | decapping enzyme, scavenger
Physiological systems
20 / 24 physiological systems tested
2 Significantly impacted by the knock-out
Mortality/aging Cardiovascular system
18 No significant impact
4 Not tested
Data collections
Gene metrics:3Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| preweaning lethality, complete penetrance | 1 supporting dataset | Dcpstm1b(EUCOMM)Hmgu | homozygote | Early adult | N/A * | ||
| prolonged RR interval | 1 supporting dataset | Dcpstm1b(EUCOMM)Hmgu | heterozygote | Early adult | 6.25x10-5 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Dcpstm1b(EUCOMM)Hmgu | homozygote | E9.5 | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Dcps mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Dcps.
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| Dcpstm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Dcpstm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Dcpstm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |