Ing2 | inhibitor of growth family, member 2
Physiological systems
17 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Behavior/neurological Mortality/aging
13 No significant impact
7 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues
| increased vertical activity | 1 supporting dataset | Ing2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.52x10-6 | ||
| increased circulating bilirubin level | 1 supporting dataset | Ing2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 9.21x10-23 | ||
| hyperactivity | 6 supporting datasets | Ing2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 2.29x10-12 | ||
| increased mean corpuscular volume | 1 supporting dataset | Ing2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 5.4x10-5 | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Ing2tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased circulating alanine transaminase level | 1 supporting dataset | Ing2tm1.1(KOMP)Vlcg | heterozygote | Early adult | 2.94x10-6 |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | n/a | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 100% (2/2) | 1.67% (7/419) |
Human diseases caused by Ing2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Ing2.
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| Ing2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Ing2tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Ing2tm88489(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |