Sec31a | SEC31 homolog A, COPII coat complex component

GeneMGI:1916412Synonyms: Sec31l1, 1810024J13Rik

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Behavior/neurological Mortality/aging

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased circulating alanine transaminase level	1 supporting dataset	Sec31a^em3(IMPC)H	heterozygote	Early adult	1.78x10^-61
increased circulating alkaline phosphatase level	1 supporting dataset	Sec31a^em3(IMPC)H	heterozygote	Early adult	6.25x10^-7
decreased fasting circulating glucose level	1 supporting dataset	Sec31a^em3(IMPC)H	heterozygote	Early adult	3.36x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Sec31a^em3(IMPC)H	homozygote	Early adult	N/A ^*
increased circulating aspartate transaminase level	1 supporting dataset	Sec31a^em3(IMPC)H	heterozygote	Early adult	1.37x10^-20
abnormal locomotor behavior	1 supporting dataset	Sec31a^em3(IMPC)H	heterozygote	Early adult	5.93x10^-5
increased grip strength	2 supporting datasets	Sec31a^em3(IMPC)H	heterozygote	Early adult	7.06x10^-7
embryonic lethality prior to tooth bud stage	1 supporting dataset	Sec31a^em3(IMPC)H	homozygote	E12.5	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Sec31a^em3(IMPC)H	homozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Sec31a.

Associated images

Loading...

Histopathology

There is no histopathology data found for Sec31a.

IMPC related publications

Loading...

External links

No external links available for Sec31a.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Sec31a^em3(IMPC)H*	Exon Deletion	‌	mouse
*Sec31a^em4(IMPC)H*	Exon Deletion	‌	mouse
*Sec31a^{tm462983(L1L2_GT2_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes