Insig1 | insulin induced gene 1
Physiological systems
21 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Craniofacial Renal/urinary system
14 No significant impact
3 Not tested
Data collections
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| impaired glucose tolerance | 1 supporting dataset | Insig1em1(IMPC)Ccpcz | homozygote | Early adult | 2.52x10-5 | ||
| increased mean corpuscular hemoglobin | 1 supporting dataset | Insig1em1(IMPC)Ccpcz | homozygote | Early adult | 2.15x10-5 | ||
| decreased locomotor activity | 1 supporting dataset | Insig1em1(IMPC)Ccpcz | homozygote | Early adult | 7.25x10-6 | ||
| decreased body weight | 1 supporting dataset | Insig1em1(IMPC)Ccpcz | homozygote | Early adult | 5.85x10-7 | ||
| increased fasting circulating glucose level | 1 supporting dataset | Insig1em1(IMPC)Ccpcz | homozygote | Early adult | 6.48x10-5 | ||
| abnormal cholesterol homeostasis | 1 supporting dataset | Insig1em1(IMPC)Ccpcz | homozygote | Early adult | 2.02x10-6 | ||
| abnormal urinary bladder morphology | 1 supporting dataset | Insig1em1(IMPC)Ccpcz | homozygote | Early adult | N/A * | ||
| abnormal maxilla morphology | 1 supporting dataset | Insig1em1(IMPC)Ccpcz | homozygote | Early adult | 2.48x10-5 | ||
| increased freezing behavior | 1 supporting dataset | Insig1em1(IMPC)Ccpcz | homozygote | Early adult | 1.02x10-7 | ||
| increased aggression | 1 supporting dataset | Insig1em1(IMPC)Ccpcz | homozygote | Early adult | 4.78x10-5 |
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Human diseases caused by Insig1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Insig1.
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| Insig1em1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Insig1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Insig1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |