Insig1 | insulin induced gene 1

GeneMGI:1916289Synonyms: Insig-1, 1810013C12Rik

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Craniofacial Renal/urinary system

14 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



impaired glucose tolerance	1 supporting dataset	Insig1^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.52x10^-5
increased mean corpuscular hemoglobin	1 supporting dataset	Insig1^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.15x10^-5
decreased locomotor activity	1 supporting dataset	Insig1^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.25x10^-6
decreased body weight	1 supporting dataset	Insig1^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.85x10^-7
increased fasting circulating glucose level	1 supporting dataset	Insig1^{em1(IMPC)Ccpcz}	homozygote	Early adult	6.48x10^-5
abnormal cholesterol homeostasis	1 supporting dataset	Insig1^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.02x10^-6
abnormal urinary bladder morphology	1 supporting dataset	Insig1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal maxilla morphology	1 supporting dataset	Insig1^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.48x10^-5
increased freezing behavior	1 supporting dataset	Insig1^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.02x10^-7
increased aggression	1 supporting dataset	Insig1^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.78x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Insig1.

Associated images

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Histopathology

There is no histopathology data found for Insig1.

IMPC related publications

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External links

No external links available for Insig1.

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*Insig1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Insig1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Insig1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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