Tatdn3 | TatD DNase domain containing 3
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Adipose tissue Skeleton
15 No significant impact
6 Not tested
Data collections
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased blood urea nitrogen level | 1 supporting dataset | Tatdn3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.49x10-5 | ||
| increased total body fat amount | 1 supporting dataset | Tatdn3tm1b(EUCOMM)Wtsi | homozygote | Early adult | 7.86x10-5 | ||
| decreased bone mineral density | 1 supporting dataset | Tatdn3tm1b(EUCOMM)Wtsi | homozygote | Early adult | 8.57x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/4) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 50% (2/4) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/4) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/4) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (4/4) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 0% (0/4) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/4) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/4) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 0% (0/4) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 0% (0/4) | 0.41% (2/491) |
Human diseases caused by Tatdn3 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Tatdn3.
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| Tatdn3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Tatdn3tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Tatdn3tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |