Mrps18c | mitochondrial ribosomal protein S18C
Physiological systems
18 / 24 physiological systems tested
3 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Mortality/aging
15 No significant impact
6 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues
| prenatal lethality | 1 supporting dataset | Mrps18ctm1.1(KOMP)Vlcg | homozygote | E18.5 | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Mrps18ctm1.1(KOMP)Vlcg | homozygote | E9.5 | N/A * | ||
| decreased circulating creatinine level | 1 supporting dataset | Mrps18ctm1.1(KOMP)Vlcg | heterozygote | Early adult | 6.3x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Mrps18ctm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| decreased hematocrit | 1 supporting dataset | Mrps18ctm1.1(KOMP)Vlcg | heterozygote | Early adult | 4.93x10-7 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Mrps18ctm1.1(KOMP)Vlcg | heterozygote | Early adult | 1.13x10-5 | ||
| decreased hemoglobin content | 1 supporting dataset | Mrps18ctm1.1(KOMP)Vlcg | heterozygote | Early adult | 4.32x10-6 |
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| adrenal gland | heterozygote | Section images | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| brain | heterozygote | Section images | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | Section images | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | Section images | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | Section images | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | Section images | 100% (2/2) | 0.41% (2/491) |
| epididymis | heterozygote | Section images | 100% (1/1) | 87.5% (21/24) |
| esophagus | heterozygote | Section images | 50% (1/2) | 1.67% (7/419) |
Human diseases caused by Mrps18c mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Mrps18c.
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