Nadk2 | NAD kinase 2, mitochondrial
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Integument Embryo Vision/eye Hematopoietic system Mortality/aging
13 No significant impact
4 Not tested
Data collections
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| abnormal embryo turning | 1 supporting dataset | Nadk2em1(IMPC)J | homozygote | E9.5 | N/A * | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Nadk2em1(IMPC)J | heterozygote | Early adult | 7.45x10-6 | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Nadk2em1(IMPC)J | heterozygote | Early adult | 4.38x10-12 | ||
| abnormal coat/hair pigmentation | 2 supporting datasets | Nadk2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.48x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Nadk2em1(IMPC)J | homozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Nadk2tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Nadk2em1(IMPC)J | heterozygote | Early adult | 8.29x10-6 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Nadk2em1(IMPC)J | homozygote | E12.5 | N/A * |
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| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | 100% (1/1) | 0.41% (2/491) |
Human diseases caused by Nadk2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Nadk2.
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| Nadk2em1(IMPC)J | Intra-exon deletion | | mouse |
| Nadk2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Nadk2tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Nadk2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |