Nadk2 | NAD kinase 2, mitochondrial
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Pigmentation Integument Embryo Vision/eye Hematopoietic system Mortality/aging
13 No significant impact
4 Not tested
Data collections
Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| abnormal embryo turning | 1 supporting dataset | Nadk2em1(IMPC)J | homozygote | E9.5 | N/A * | ||
| persistence of hyaloid vascular system | 1 supporting dataset | Nadk2em1(IMPC)J | heterozygote | Early adult | 7.45x10-6 | ||
| decreased fasting circulating glucose level | 1 supporting dataset | Nadk2em1(IMPC)J | heterozygote | Early adult | 4.38x10-12 | ||
| abnormal coat/hair pigmentation | 2 supporting datasets | Nadk2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.48x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Nadk2em1(IMPC)J | homozygote | Early adult | N/A * | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Nadk2tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased mean corpuscular hemoglobin concentration | 1 supporting dataset | Nadk2em1(IMPC)J | heterozygote | Early adult | 8.29x10-6 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Nadk2em1(IMPC)J | homozygote | E12.5 | N/A * |
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External links
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| Nadk2em1(IMPC)J | Intra-exon deletion | | mouse |
| Nadk2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Nadk2tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Nadk2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |